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In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation
[article]
2021
bioRxiv
pre-print
Amyloid-beta (Ab) aggregation mediated neuronal membrane deformation, although poorly understood, is implicated in Alzheimer's Disease (AD). Particularly, whether Ab aggregation can induce neuronal demyelination remains unknown. Here we show that Aβ-40 binds and induces extensive tubulation in the myelin membrane in vitro. The binding of Aβ-40 depends predominantly on the lipid packing defect densities and electrostatic interactions and results in rigidification of the myelin membrane in the
doi:10.1101/2021.08.13.456302
fatcat:hb3jk3nsgbebxn52ndgeacwdwq