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Heme and hemoglobin suppress amyloid β–mediated inflammatory activation of mouse astrocytes
Journal of Biological Chemistry
Glial immune activity is a key feature of Alzheimer's disease (AD). Given that the blood factors heme and hemoglobin (Hb) are both elevated in AD tissues and have immunomodulatory roles, here we sought to interrogate their roles in modulating amyloid β (Aβ)-mediated inflammatory activation of astrocytes. We discovered that heme and Hb suppress immune activity of primary mouse astrocytes by reducing expression of several proinflammatory cytokines (e.g. RANTES) and the scavenger receptor CD36,doi:10.1074/jbc.ra117.001050 pmid:29871926 fatcat:whq5zd4rzzbr5jupe55omghi7q