I-VIVO ATIMALARIAL STUDY OF PITC2 of Pluchea indica (L.) Less AGAIST Plasmodium berghei AD Plasmodium yolli MODEL

Abhishek Kundu, Debanjan Sen, Tapan Chatterjee
The antimalarial properties of crude extract and PITC-2 a compound isolated from tissue cultured plant Pluchea indica traditionally used medicine in various regions of India was evaluated for antimalarial property. The air-dried powdered plant part (roots) was extracted, sequentially with solvents of increased polarity (methanol, butanol, petroleum-ether, and ethyl-acetate). The extract was then administrated orally into albino mice infected with malarial parasites at dose of 100 and 300
more » ... ay keeping Chloroquine and Sodium artisunate as standard. Ethyl acetate insoluble fraction and isolated compound PITC2 prove significant antimalarial effects.