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Trypanocidal activity of organotin chlorides onTrypanosomabrucei-infected mice
The organotin compounds dibulyltin (DBTC) and diphenyltin dichlorides (DPTC) were tested for trypanocidal activity on a Trypanosoma brucei-infected mice model. At a dose of 10 mg DBTC and 15 mg DPTC/kg/day for five consecutive days, they cleared the parasites from the peripheral blood of the infected mice. Subinoculation of some healthy mice with the homogenates of liver, spleen, kidney, cerebrospinal fluid and blood from the mice considered cured, showed a few cases of relapse. The LD50 ofdoi:10.1051/parasite/2000071043 pmid:10743647 fatcat:3vhyllw4sva45bcbkr43l3xvma