SOLUBILIZATION OF SOME NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDs) BY PLURONIC F-127 BLOCK COPOLYMER

M. EL-Badry, M. Fathy, M. Abdel Mohsen
2004 Bulletin of Pharmaceutical Sciences  
The change in heat of solution (H), free energy (G) and entropy (S) as a result of solubilization of the investigated drugs were calculated. The data prevailed that, the presence of Pl. F-127 energetically favors the solubility of the used drugs and more favorable by increasing the surfactant concentration. The dissolution study was performed for these drugs. Pl. F-127 proved its ability to enhance the dissolution rate of the investigated water insoluble drugs.
doi:10.21608/bfsa.2004.65384 fatcat:xxjj644vljbnxjrol7j5kxg3ca