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Par-4 Sensitizes Human Colon Cancer Cells to Chemoradiotherapy
Journal of Cancer Therapy
Despite aggressive treatment and recent advances, cancers of the colon and rectum remain a leading cause of death worldwide. In the case of rectal cancer, chemo-radiotherapy (CRT) is given prior to surgery to provide a greater chance of sphincter sparing surgery and lower the incidence of local recurrence. However, toxicity of CRT remains a problem. The tumor suppressor, serves to sensitize tumor cells to chemotherapy and radiation therapy. This study tested the effects of increased Par-4doi:10.4236/jct.2011.24074 fatcat:vdnxibboebf6zgoms6desij6rm