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Three indicator displacement assays are described for the detection of phosphatidylserine in a bilayer membrane. A series of Zn 2+ -dipicolylamine coordination compounds are used to bind selectively to the phosphatidylserine and act as a colorimetric chemosensing ensemble when combined with the UV-Vis indictor pyrocatechol violet. A similar displacement assay uses a coumarin methylsulfonate derivative as a fluorescent indicator, and a third assay involves quenching of calcein fluorescence by Cudoi:10.1039/b500522a fatcat:atyrwpnzofaajoxe62q5ljvk3m