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MORFEE: a new tool for detecting and annotating single nucleotide variants creating premature ATG codons from VCF files
[article]
2020
bioRxiv
pre-print
Variants in 5'UTR regions that create upstream translation initiation AUG codons are a class of neglected non coding variations. When they associate with a premature stop codon and create upstream open reading frames (uORFs) whose translation competes with that of natural proteins, they can have strong impact on human diseases. We here describe MORFEE, a new bioinformatics tool that detects, annotates and predicts, from a standard VCF file, the creation of uORF by any 5'UTR variants on uORF
doi:10.1101/2020.03.29.012054
fatcat:rfpernksovb2fmkw2wnxdtj34i