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PO-420 Mechanisms of action of anti-proliferative lichen compound protolichesterinic acid
2018
PO-416 Cytotoxicity of Ru (II) and Ru (III) salen complexes against breast and colorectal cancer cell lines
unpublished
on growth factor signalling are secondary. PA inhibits DNA replication and earlier studies indicated direct effects of PA on HIV reverse transcriptase (RT) and DNA polymerase. RT inhibitors are known to affect mitochondria. Material and methods Molecular modelling software (Glide, Schrödinger, LLC) was used to test for the ability of PA to bind onto DNA polymerases a, b, g and . The crystal structures of polymerases were acquired from Protein Data Bank (PDB ID: 4QCL, 5TB8, 4ZTZ and 5A9F,
doi:10.1136/esmoopen-2018-eacr25.447
fatcat:m7v2c7d7lfcs5icnffrzlunjmy