Tracheal intubation can result in extensive changes in heart rate and blood pressure. The aim of this study was to investigate the effect of smearing tracheal tube cuff with diltiazem gel on cardiovascular changes in patients who underwent laparoscopic cholecystectomy surgery. Methods: This clinical trial study was conducted on 80 patients who underwent laparoscopic cholecystectomy surgery in Imam Reza hospital, Kermanshah, Iran. Patients were randomly divided in two groups of intervention

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... heal tube cuff smeared with 2% diltiazem gel) and control (tracheal tube cuff smeared with sterile water-soluble lubricant gel) using permuted block technique. Cardiovascular changes (heart rate, systolic blood pressure, diastolic blood pressure, and dysrhythmia) was measured before the surgery, and immediately and 5 minutes after intubation, every 15 minutes during the surgery, at the beginning of the recovery, and 15 and 30 minutes after entering the recovery. Findings: The mean heart rate, systolic blood pressure, and diastolic blood pressure in patients receiving diltiazem gel was significantly decreased compared to control group (P < 0.050). Moreover, according to the results of repeated measures ANOVA, in the group receiving diltiazem gel, the mean of measured variables showed a significant difference in various times (P < 0.050). Conclusion: Regarding the effect of smearing tracheal tube cuff with diltiazem gel on decreasing cardiovascular changes, diltiazem gel can be used to prevent mentioned responses or to suppress them.