Zoledronic Acid Induces a Significant Decrease of Circulating Endothelial Cells and Circulating Endothelial Precursor Cells in the Early Prostate Cancer Neoadjuvant Setting

Daniele Santini, Alice Zoccoli, Chiara Gregorj, Melania Di Cerbo, Michele Iuliani, Francesco Pantano, Rita Zamarchi, Federico Sergi, Gerardo Flammia, Maurizio Buscarini, Sergio Rizzo, Giuseppe Cicero (+4 others)
2013 Oncology  
reduction of mean percentage of CECs and CEPs after initiation of ZOL treatment [p = 0.014 (at day 3) and p = 0.012 (at day 84), respectively]. Conclusion: These preliminary results demonstrate that ZOL could exert an antiangiogenic effect in early prostate cancer through CEP and CEC modulation.
doi:10.1159/000347226 pmid:24335337 fatcat:lwc4z4dkx5c53iffk7ipy32s3e