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Building on the pioneering work of Bill DeGrado and colleagues in the late nineteen-eighties, protein design approaches have revealed many fundamental features of protein structure and stability. We are now in the era that the early work presagedthe design of new proteins with practical applications and uses. Here we briefly survey some past milestones in protein design, in addition to highlighting recent progress and future aspirations.doi:10.1002/bip.22639 pmid:25784145 pmcid:PMC4856012 fatcat:x5ecxnecfvfepffebuawfd3v4i