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P2X1 receptor-mediated pressor responses in the anesthetized mouse
2012
Acta Pharmaceutica Sinica B
P2X 1 receptors and adrenoceptors are mainly responsible for vasoconstriction in a variety of blood vessels. However, previous studies have shown that a,b-methylene adenosine 5 0 -triphosphate (a,b-MeATP), a stable analogue of ATP, can induce both pressor and depressor responses in laboratory animals. In this study, the effects of increasing intravenous doses of a,b-MeATP and noradrenaline (NA) (0-30 nmol/kg) administered at 20 min intervals on systolic (SBP), diastolic (DBP) and mean (MBP)
doi:10.1016/j.apsb.2012.04.005
fatcat:77cwb4wczbeh7jtnadeijd7hre