gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study

C Shin, HB Pedersen, JO McNamara
1985 Journal of Neuroscience  
Quantitative radiohistochemistry was utilized to study alterations of y-aminobutyric acid (GABA) and benzodiazepine receptors in the kindling model of epilepsy. The radioligands used for GABA and benzodiazepine receptors were [3H] muscimol and [3H]flunitrazepam, respectively. and GABA transaminase inhibitors, which presumably enhance GABA neurotransmission, also exert anticonvulsant effects in the kindling model (for review, see McNamara et al., 1985).
doi:10.1523/jneurosci.05-10-02696.1985 pmid:2995608 fatcat:wjhmh5avn5ajrmc6medyirwrcm