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Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) cytokine family and known to be induced in the nervous system as a result of cell stress. OSM is expressed in most human brain tumors, but the effects on tumor cells are unclear. The cytokine is known to activate the JAK/STAT signaling pathway by binding to its receptors gp130/OSMß or gp130/LIFRß and thereby initiating activation or suppression of a number of STAT target genes. The objective of the study was to identify OSM-regulateddoi:10.3892/ijo.31.6.1457 fatcat:mqztfbbvtrbqjaacex4cwbuljq