Objective: The inflammatory pathway genes myeloperoxidase (MPO) is involved with regulation of inflammation through reactions with hydrogen peroxide (H2O2).The MPO enzyme is expressed abundantly in neutrophils, in which its antimicrobial function converts (H2O2) to the bacterocidal and DNA- damaging hypochlorous acid.Our aim was in this study to investigate whether there is a relationship between MPO gene (rs 2333227) polymorphysm (-463G/A) and neural tube defects. Method: Grup 1 was consisted

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... f 33 pregnant women who were in 13-24 th gestational week with fetal neural tube defects, Grup 2 was consisted of 150 healthy pregnant women (in 13-24th gestational week) without any medical problem and any fetal anomaly.DNA's which were isolated from peripheral blood were investigated by PCR-RFLP method for MPO gene (rs 2333227) promotor polymorhysm (-463G/A).The results were analysed with qi-square and de-Finetti programme. Results: There was not a statistically significant difference between two groups for maternal age and pregnancy week.There was no difference for HWE in two Groups.When two groups results were compared for MPO polymorphysm, there was not a statistically significant difference in genotype distribution and allel frequency. Conclusion: This is the first study in the literature which is investigated MPO (-463G/A) promotor polymorhysm in pregnant who have a child with neural tube defect and was not find a significant correlation.We decided that we need to investigate other MPO polymorphysm and other gene polymorhysm which could be effective.