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Celastrol attenuates the remodeling of pulmonary vascular and right ventricular in monocrotaline-induced pulmonary arterial hypertension in rat
[report]
2021
Pulmonary arterial hypertension is a progressive angio-proliferative disease associated with high morbidity and mortality rates. Although the histopathology of pulmonary arterial hypertension is well described, its therapeutic option remains unsatisfactory.It is increasing being recognized that early and persistent inflammation plays an indispensable role in the development and progression of PAH.Celastrol, isolated from the root extracts of Tripterygium wilfordii (thunder god vine), is a
doi:10.17590/asr.0000266
fatcat:m4xwedp2sba7ja3s57lyu2pl4u