Survival Analysis of Scalp Angiosarcoma Patients for Treatment Modalities in our Hospital Over the Past 28 Years

Motoki Nakamura
2014 Journal of Clinical & Experimental Dermatology Research  
Survival and statistical analysis Disease-specific survival was calculated by the Kaplan and Meier method. Deaths caused by the disease were treated as an endpoint for disease-specific survival. Other deaths were treated as censored observations. The study was approved by the Ethics Committee of Abstract Background: Angiosarcoma is a malignant neoplastic disease that often occurs in older people. The prognosis is poor and treatment effectiveness remains controversial. Objective: We examined
more » ... s of scalp angiosarcoma treated in Nagoya City University Hospital from 1985 to 2013 and retrospectively analyzed treatment effectiveness. Methods and materials: We identified 21 scalp angiosarcoma patients and followed up 18 patients among them. Disease-specific survival was calculated by the Kaplan and Meier method and compared between treatments. Results: Median patient age was 75 years, and 14 patients (78%) were over 70 years of age. The 2-and 5-year disease-specific survival was 62.7% and 26.3%, respectively. Overall survival was significantly longer in those receiving radiotherapy or combination therapy with radiotherapy and chemotherapy. Thirteen patients (72%) received chemotherapy and 12 patients received taxane-based chemotherapy. Although toxicity occurred in 11 patients receiving taxane-based chemotherapy, most cases were grade 1 or 2. Conclusions: Combination therapy with radiotherapy and taxane-based chemotherapy may be an effective medical treatment for scalp angiosarcoma, and can be performed safely even in older patients. Figure 1: Number of scalp angiosarcoma patients who visited our hospital.
doi:10.4172/2155-9554.1000202 fatcat:k3bztamv2fhyfi2oy5ubu3xdsy