A Case of Sorafenib-induced DRESS Syndrome in Hepatocelluar Carcinoma

Dong Kyun Kim, Sung Woo Lee, Hwa Seong Nam, Dong Sub Jeon, Na Rae Park, Young Hee Nam, Soo Keol Lee, Yang Hyun Baek, Sang Young Han, Sung Wook Lee
2016 Korean Journal of Gastroenterology  
Sorafenib is currently the only targeted therapy available for advanced stage hepatocellular carcinoma (HCC). Cutaneous adverse events associated with sorafenib treatment include hand-foot skin reaction, but there has been no report of drug reaction (or rash) with eosinophilia and systemic symptoms (DRESS) syndrome. Here, we report a case of 72-year-old man with HCC and alcoholic liver cirrhosis who developed skin eruptions, fever, eosinophilia, and deteriorated hepatic and renal function under
more » ... sorafenib treatment. He has since successfully recovered with conservative care. (Korean J Gastroenterol 2016;67:337-340)
doi:10.4166/kjg.2016.67.6.337 pmid:27312836 fatcat:fw5gsaumuzcy7bsu2rxty6623y