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The efficacy of pyridoxal phosphate (PLP) compared to pyridoxine (PN) in the control of idiopathic intractable epilepsy was studied in 94 children, aged 8 months to 15 years, at the National Taiwan University Hospital, Taipei, Taiwan. Fifty-seven patients had generalized seizures (infantile spasms in 13) and 37 had focal seizures. Intravenous PLP 10 mg/kg was followed by 10 mg/kg/day orally in 4 divided doses. The dose was increased to 50 mg/kg/day if seizures recurred within 24 hours of thedoi:10.15844/pedneurbriefs-19-5-12 fatcat:7rulltm7ordjteahd5dh4vly4q