ACTH Therapy in Epileptic Spasms without Hypsarrhythmia
Pediatric Neurology Briefs
The efficacy of pyridoxal phosphate (PLP) compared to pyridoxine (PN) in the control of idiopathic intractable epilepsy was studied in 94 children, aged 8 months to 15 years, at the National Taiwan University Hospital, Taipei, Taiwan. Fifty-seven patients had generalized seizures (infantile spasms in 13) and 37 had focal seizures. Intravenous PLP 10 mg/kg was followed by 10 mg/kg/day orally in 4 divided doses. The dose was increased to 50 mg/kg/day if seizures recurred within 24 hours of the
... 24 hours of the first injection. PN was substituted if seizures were completely controlled by PLP. Eleven (11.7%) responded dramatically to PLP (6 had infantile spasms), and of these, 5 also responded to PN. The mean ages of vixamin B6 responders and non-responders were 6.3 and 72 months, respectively. No side effects occurred, and tests of sensory and motor nerve conduction were normal. ( Wang H-S, Kuo M-F, Chou M-L et al. Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. Arch Dis Child May 2005;90:512-515).