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Structural and Conformational Probing of 2-Acetylaminofluorene-Modified -1, -2 and -3 Slipped Mutagenic Intermediates
2-Acetylaminofluorene (AAF) is a prototype arylamine carcinogen that forms C8substituted dG-adduct (dG-C8-AAF) as a major DNA damage. The bulky dG-C8-AAF lesion is known to induce -1, -2, or -3 frameshift mutations depending on the base sequences around the lesion. We hypothesize that the stability of bulged-out structures slipped mutagenic intermediate (SMI) facilitates primer elongation, hence manifestation of frameshift mutations. The objective of the present study was to probe thedoi:10.23860/thesis-sandineni-anusha-2013 fatcat:cl4a2vbtrred5jzztwy2ez6eq4