Model of the study: This is an exploratory and descriptive study which was executed in sector of Nutrology nursing at University Hospital, Faculty of Medicine of Ribeirão Preto, University of São Paulo (HCFMRP-USP). Objective: The aim of this research was to evaluate the perception of quality of life of individuals with short bowel syndrome (SBS) with the help of the Quality of Life Core -30 Questionnaire (QLQ -C30). Methods: The instrument used was the EORTC-QLQ-C30 (European Organization for

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... esearch and Treatment of Cancer Quality of Life Questionnaire/ Quality of Life Core -30 Questionnaire) version 3.0 in Portuguese. The study was conducted on six patients with SBS. Results: The applicability of the questionnaire was adequate and the mean score obtained for this sample (70.7) was considered to be satisfactory. Conclusions: The most affected domains were: Emotional Function and Symptoms: pain, insomnia, fatigue, and diarrhea. The application of the QLQ -C30 permitted us to evaluate the perception of the patient regarding his condition and quality of life, important aspects that should be considered by the team.