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Nucleated transcriptional condensates amplify gene expression
[article]
2019
bioRxiv
pre-print
Liquid-liquid phase separation is thought to underly gene transcription, through the condensation of the large-scale nucleolus, or in smaller assemblies known as transcriptional hubs or condensates. However, phase separation has not yet been directly linked with transcriptional output, and our biophysical understanding of transcription dynamics is poor. Here, we utilize an optogenetic approach to control condensation of key FET-family transcriptional regulators, particularly TAF15. We show that
doi:10.1101/737387
fatcat:dbewvh2rzje45cwwx5mxjpzvty