Biosynthesis of Trichothecene Mycotoxins in Fusarium culmorum Cultures

Nigel C. P. Baldwin, Barrie W. Bycroft, Paul M. Dewick, John Gilbert, Ian Holden
1985 Zeitschrift für Naturforschung C - A Journal of Biosciences  
A high yielding production of the trichothecene mycotoxin 3-acetyldeoxynivalenol (3-AcDON) in cultures of Fusarium culmorum is described. By supplying [14C]acetate, 14C-labelled 3-AcDON suitable for further metabolic studies has been obtained. The pattern of labelling has been ascertained by using 13C-labelled acetate precursors, and is in line with established biosynthetic data. A second trichothecene produced in significant amounts by F. culmorum has been identified as 3α, 15-diacetoxy-7α,
more » ... 15-diacetoxy-7α, 8α-dihydroxy-12, 13-epoxytrichothec-9-ene (7α, 8α-dihydroxycalonec-trin).
doi:10.1515/znc-1985-7-810 fatcat:gzvy7hbmgfbxpmyd6fyrbqjgrm