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Stem Cell Differentiation as a Non-Markov Stochastic Process
2017
Cell Systems
Graphical Abstract Highlights d We profile individual stem cells as they differentiate along the neural lineage d Regulatory network changes and increased cell variability accompany differentiation d Analysis of dynamics with a hidden Markov model reveals unobserved molecular states d We propose a model of stem cell differentiation as a non-Markov stochastic process SUMMARY Pluripotent stem cells can self-renew in culture and differentiate along all somatic lineages in vivo. While much is known
doi:10.1016/j.cels.2017.08.009
pmid:28957659
pmcid:PMC5624514
fatcat:hh377pbol5azrj2yeew6e3eehi