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<div> <p>In clinical chemotherapy, some basic drugs cannot enter the hydrophobic cell membrane because of ionization in acidic tumor microenvironment, a phenomenon known as ion trapping. In this study, we developed a method to visualize this ion trapping phenomenon by utilizing a pH-responsive ratiometric AIEgen, dihydro berberine (dhBBR). By observing the intracellular fluorescence of dhBBR, we found that non-ionized dhBBR can enter cells easier than ionized forms, which is in accordance withdoi:10.26434/chemrxiv.12122763.v1 fatcat:jo2et7tnubbhljw56z77ukb6dy