G445(P) Experiences of accessing health care for low birth weight infants among care givers and health care providers in homa bay county of western kenya

SE Unsworth, F Were, HC Barsosio, D Juma, HM Nabwera
2020 Abstracts   unpublished
electroencephalogram and computer tomography suggestive of encephalitis, over one year. In these patients, VE was if CSF cell count was <1000 cells/mm3(lymphocyte predominance) and absence of non-viral pathogens in the CSF or blood. BM was CSF cell count > 1000 cells/mm3(polymorph predominance) and CSF protein >0.45 g/L and CSF/plasma glucose <40%, and/or positive Gram stain and/or bacterial culture. JE was VE with ! 40 units of anti JE-IgM in the CSF and/or serum. All CNS infections were
more » ... fections were defined as, suspected cases by treating clinician with or without fever with LP showing CSF cells > 4/mm 3 . Results Out of 38, bacterial meningitis was found in 47%, JE 21% and other causes in 32%. Although WHO definition of AES was not significantly associated with all CNS infections (p-value= 0.069), it was significantly associated with VE (p-value£0.001, sensitivity 74%, specificity 93%, PPV 94%, NPV 70%) and BM (p-value£0.001, sensitivity 30%, specificity 7%, PPV 33%, NPV 6%). Likewise, CSF criteria(cytology and biochemistry) for diagnosing JE was significantly associated with confirmed diagnosis of JE(p-value= 0.001). Conclusion We validate WHO AES definition of BM and VE and CSF cytology and biochemistry analysis for the diagnosis of JE, as a significantly useful screening tool for children with these diseases specially in resource poor settings, endemic areas and confirmatory tests were not easily available.
doi:10.1136/archdischild-2020-rcpch.383 fatcat:ykdrnmigbfhjpgqr2wbi567yee