Poloxamers, PEO-PPO-PEO triblock copolymers, are well-known thermo-reversible sol-gel transition polymers that have great potential for use in biomedical applications, but have several drawbacks such as the weak mechanical properties and physical stability. In this study, we tried to modify and improve the physicochemical properties of poloxamer gels by preparation of acyl glycol chitosan-containing poloxamer gels. Various poloxamer gels with different compositions were prepared and

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... d in terms of thermo-reversible sol-gel transition properties, mechanical properties, and physical stability. These hydrogel systems could demonstrate not only enhanced physicochemical and thermo-responsive properties but also low cytotoxicity, allowing poloxamer gels to extend their potential application area.