MicroRNAs As Novel Regulators of Angiogenesis

Y. Suarez, W. C. Sessa
2009 Circulation Research  
MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their
more » ... ial therapeutic applications for vascular diseases associated with abnormal angiogenesis. (Circ Res. 2009;104:442-454.)
doi:10.1161/circresaha.108.191270 pmid:19246688 pmcid:PMC2760389 fatcat:nr5zuwjfn5fbfaqggubvoohqxu