Whole-Cell Bacterial Detection Using a Versatile Localized Surface Plasmon Resonance Biosensing Platform

Jiayun Hu
2018
Bacterial sensing is gaining lots of interest in the scientific community as well as health and food industries due to its profound impact in human health. With the worldwide burgeoning drug resistance among bacteria, the same bacterial infection now becomes more difficult and costly to treat. The current gold standard bacterial diagnostic methods suffer from being slow, typically several days to a week for infection identification, which unintentionally promotes the use of wide-spectrum
more » ... tics as an initial treatment, prompting the multidrug resistance crisis. To address this issue, various types of biosensors have been developed; however, it is rather challenging to be rapid, sensitive, selective, affordable, easy to operate, and to have a clinically relevant dynamic range. Therefore, achieving all aforementioned merits simultaneously is going to be the central focus of biosensor development. The research presented here describes the development of a versatile whole-cell bacterial sensing platform and its applications to detect pathogens using localized surface plasmon resonance (LSPR) spectroscopy. Specifically, Pseudomonas aeruginosa and
doi:10.7274/xd07gq70v7b fatcat:4pbrabdanjaujlw4afnqnromr4