Objective: To study the efficacy of adjuvant zinc gluconate therapy for infantile rotavirus enteritis diarrhea. Methods: Children who were hospitalized in Baoji Central Hospital due to rotavirus enteritis diarrhea between March 2014 and April 2017 were selected as the research subjects and divided into the observation group who received zinc gluconate combined with conventional treatment and the control group who received conventional treatment. The contents of inflammatory cytokines,

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... ulin and complement in serum, the contents of T cell subsets in peripheral blood and the contents of intestinal flora in feces were determined before treatment and after 10 d of treatment. Results: after 10 d of treatment, TNF-α, IL-1β, IL-8, sIL-2R, DAO and D-lactic acid contents in serum, CD8+ contents in peripheral blood as well as Escherichia coli contents in feces of both groups were lower than those before treatment whereas C3, C4, IgA and IgG contents in serum, CD3+ and CD4+ contents in peripheral blood as well as bifidobacterium and lactobacillus contents in feces were higher than those before treatment, and TNF-α, IL-1β, IL-8, sIL-2R, DAO and D-lactic acid contents in serum, CD8+ content in peripheral blood as well as Escherichia coli content in feces of observation group were lower than those of control group whereas C3, C4, IgA and IgG contents in serum, CD3+ and CD4+ contents in peripheral blood as well as bifidobacterium and lactobacillus contents in feces were higher than those of control group. Conclusion: Adjuvant zinc gluconate therapy for infantile rotavirus enteritis diarrhea can inhibit the inflammatory response and improve the immune response and intestinal mucosal barrier function.