A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference
2015
Biochimica et Biophysica Acta - Biomembranes
With the ultimate goal of detailed structural analysis of mammalian and particularly human voltage-gated sodium channels (VGSCs), we have investigated the relative stability of human and rat VGSCs and compared them with electric eel VGSC. We found that NaV1.3 from rat was the most stable after detergent solubilisation. The order of stability was rNaV1.3>hNaV1.2>hNaV1.1>hNaV1.6>hNaV1.3>hNaV1.4. However, a comparison with the VGSC from Electrophorus electricus, which is most similar to NaV1.4,
doi:10.1016/j.bbamem.2015.03.021
pmid:25838126
pmcid:PMC4557063
fatcat:v7jnhkohivfn5hgutsvvf6q7aq