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The cohort multiple randomized controlled trial design: a valid and efficient alternative to pragmatic trials?
2016
International Journal of Epidemiology
Randomized controlled trials (RCTs)-the gold standard for evaluating the effects of medical interventions-are notoriously challenging in terms of logistics, planning and costs. The cohort multiple randomized controlled trial approach is designed to facilitate randomized trials for pragmatic evaluation of (new) interventions and is a promising variation from conventional pragmatic RCTs. In this paper, we evaluate methodological challenges of conducting an RCT within a cohort. We argue that
doi:10.1093/ije/dyw050
pmid:27118559
fatcat:cvuyt7wi5nehrcidohdckhs7xq