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Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, thedoi:10.2147/ijn.s72998 pmid:25565807 pmcid:PMC4275058 fatcat:2uyo64f4hffhzg64fdx74j23he