Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

Dongwoo Khang, Yeon Kyung Lee, Eun-Ju Choi, Thomas J. Webster, Sang-Hyun Kim
2014 International Journal of Nanomedicine  
Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the
more » ... g of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses.
doi:10.2147/ijn.s72998 pmid:25565807 pmcid:PMC4275058 fatcat:2uyo64f4hffhzg64fdx74j23he