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Total Synthesis and Structural Revision of a Harziane Diterpenoid
[post]
2019
unpublished
Preserved Fulltext
The first total synthesis of nominal harziane diterpenoid is disclosed, whose spectral characteristics did not match those of the reported natural product. Stereochemical analysis and subsequent synthesis of the epimeric tertiary alcohol led to reassignment of configuration of the natural product. At the heart of the synthesis is an enyne cycloisomerization that sets a key quaternary stereocenter within a cyclobutane with high diastereocontrol. The route features strategies for the synthesis of
doi:10.26434/chemrxiv.9250340.v1
fatcat:lwqydcd6jvhqpmjchlkhxs4cem