The influence of cognitive reserve on inter-individual variability in resting-state cerebral metabolism in normal aging

Christine Bastin, Eric Salmon, Mohamed Ali Bahri, Brigitte Landau, Andreas Fellgiebel, Dorothée Feyers, Fabienne Collette, Gaël Chetelat, Igor Yakushev
2012 Alzheimer's & Dementia  
atrophy and intracellular accumulations of tau, With the exception of a small number of familial forms the causes for FTLD are unknown. With our plasma proteomics approach we identified novel disease pathways that may open possibilities for treatment and diagnostics. Methods: We employed medium scale plasma proteomics, measuring more than 600 soluble cellular communication factors in plasma from control (n ¼ 83) and FTLD (n ¼ 92) patients with semantic dementia, as well as from FTLD patients
more » ... h a familial Progranulin mutation (n ¼ 24). We are using an antibody microarray based approach in combination with statistical and computational tools to identify altered pathways. Results: Our analysis revealed a deregulation of inflammatory markers, most prominently in the TNF-alpha and IL-1 pathways. We further confirmed an increase in TNF-alpha in the plasma of FTLD patients by ELISA. Currently we are in the process of analyzing the immune phenotype of FTLD patients and comparing it to healthy controls. Conclusions: Our results show evidence for a novel immune phenotype in FTLD patients with TDP-43 pathology. This opens up possibilities for a targeted anti-inflammatory therapy for this disease.
doi:10.1016/j.jalz.2012.05.193 fatcat:yjnnxqzzwncd3ob5dzwpct3g5u