Concise synthesis of (S)-(-)-Propranolol: Using acid catalysed kinetic resolution

Narinder Singh, Anil Kumar, Rajinder Singh
Journal of Chemical and Pharmaceutical Research   unpublished
Enantiomerically pure (S)-propranolol was prepared by using Zn(NO 3) 2 / (+)-tartaric acid for the resolution of terminal epoxide. This process is carried out at 75°C temperature in excellent enantioselectivity via kinetic resolution of key Intermediate α-naphthyl glycidyl ether.