TNF-α is a cytokine that plays an active role in the pathogenesis of gastritis. The correlation of TNF-α levels in the gastric mucosa with the severity of gastritis has long been known. However, few studies have assessed TNF-α levels in serum of gastritis patients. This study aims to evaluate correlation between serum TNF-α level with the degree of gastritis based on histopathology. Method: A cross sectional study on eighty gastritis patients that fulfilled the inclusion criteria underwent

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... TNF-α examination, endoscopy, and biopsy. Rapid urease test was used for diagnosis of H. pylori infection. The severity of gastritis based on lymphocyte infiltration, neutrophil infiltration, atrophy, and intestinal metaplasia according to Updated Sydney System. Univariate and bivariate analysis (Chi-square, fisher's exact, spearman correlation, and independent t-test) were done using SPSS version 22. Results: There were 41.25% patients infected with Helicobacter pylori. Serum TNF-α levels in the infected group were significantly higher compared to negative H. pylori (p < 0.05). There was significant positive correlation between serum TNF-α levels and degree of gastritis based on lymphocyte infiltration (r = 0.333; p = 0.003). Conclusion: There was a significant positive correlation between serum TNF-α level with the severity of gastritis based on lymphocyte infiltration. ABSTRAK Latar belakang: TNF-α merupakan sitokin yang berperan aktif pada patogenesis gastritis. Korelasi kadar TNF-α pada mukosa lambung dengan derajat keparahan gastritis telah lama diketahui. Meskipun demikian, hanya sedikit penelitian yang menilai kadar TNF-α dari serum pasien gastritis. Penelitian ini bertujuan menilai kadar serum TNF-α dan korelasinya dengan derajat keparahan gastritis secara histopatologi. Metode: Penelitian potong lintang terhadap 80 pasien gastritis yang memenuhi kriteria inklusi. Dilakukan pemeriksaan kadar serum TNF-α, endoskopi, dan biopsi. Rapid urease test digunakan untuk diagnosis infeksi H. pylori. Derajat keparahan dinilai dari infiltrasi limfosit, infiltrasi neutrofil, atrofi, dan metaplasia intestinal yang mengacu pada Updated Sydney System. Analisis univariat dan bivariat (Chi-square, fisher's exact, korelasi spearman dan independent t-test) dengan SPSS versi 22. Hasil: Pasien yang terinfeksi H. pylori sebesar 41,25%. Kadar TNF-α serum secara signifikan lebih tinggi pada kelompok yang terinfeksi H. pylori dibandingkan kelompok yang tidak terinfeksi H. pylori (p < 0,05). Terdapat korelasi positif antara kadar serum TNF-α dengan derajat gastritis berdasarkan infiltrasi limfosit [r = 0,333 dengan p = 0,003]. Simpulan: Terdapat korelasi positif yang signifikan antara kadar TNF-α serum dengan derajat keparahan gastritis berdasarkan infiltrasi limfosit.