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Rab27a: ligand and interactome discovery for a secretory GTPase
2018
Rab27a is a small GTPase belonging to the Ras superfamily. Normally involved in vesicle transport and docking, numerous studies from the past two decades have documented a positive correlation between its overexpression in tumour cells and the invasiveness of the cancer. These findings strongly suggest that Rab27a could be a novel cancer drug target, yet, the dearth of clinically successful drugs targeting other oncogenic members of the Ras superfamily reflects the difficulty of applying
doi:10.25560/57954
fatcat:vqc75caolvcrfn22i2uig4qwyu