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Definition of the Sites of Interaction between the Protein Tyrosine Phosphatase SHP-1 and CD22
1999
Journal of Biological Chemistry
Preserved Fulltext
CD22 phosphorylation is an early event of B cell antigen receptor engagement and results in the recruitment of the negative regulatory tyrosine phosphatase, SHP-1. Peptides representing the potential phosphorylation sites within the cytoplasmic domain of CD22 have been used to stimulate SHP-1 catalytic activity and to inhibit the binding of SHP-1 to CD22 (
doi:10.1074/jbc.274.4.2303
pmid:9890995
fatcat:lb57qwxp7jf7tczzwkhxw5rgmu