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Promising non-viral vector for efficient and versatile delivery of mRNA for antigen-specific immunotherapy
2020
Cell and Gene Therapy Insights
Cellular immunotherapy involves the modification of immune cells in vivo or ex vivo to elicit, modulate or suppress immune responses. Modification by mRNA has become an attractive alternative to DNA vectors as a non-viral delivery approach, due to high transfection efficiency including in non-dividing cells. However, widespread adoption of this strategy is currently limited by the lack of commercially available ready-to-use reagents for in vivo delivery of mRNA. In this study, we evaluate the
doi:10.18609/cgti.2020.154
fatcat:jvovy73dgvckbkhcqjvr7qjb4q