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Membrane proteins are estimated to be the targets of 50% of drugs that are currently in development, yet we have few membrane protein crystal structures. As a result, for a membrane protein of interest, the much-needed structural information usually comes from a homology model. Current homology modelling software is optimized for globular proteins, and ignores the constraints that the membrane is known to place on protein structure. Our Memoir server produces homology models using alignment anddoi:10.1093/nar/gkt331 pmid:23640332 pmcid:PMC3692111 fatcat:az47ghyxfrfjbo4s2qz4inizji