P-280 Metalworking fluids and cancer incidence in the UAW-GM autoworkers cohort

Hilary Colbeth, Kevin Chen, Sally Picciotto, Sadie Costello, Ellen Eisen
2021 Poster Presentations   unpublished
Methods We conducted a systematic review on observational studies of metal levels from biological matrices, and dietary and occupational/environmental sources among PD patients and controls. We searched the PubMed/MEDLINE, EMBASE and Cochrane databases up to July 2020. Metal species included manganese, iron, copper, lead, mercury, aluminum, calcium, selenium, zinc, magnesium, cadmium, chromium and nickel, and the outcome was idiopathic PD. We applied an adapted Newcastle-Ottawa Scale (NOS) and
more » ... previously established exposure assessment rating to evaluate each individual study. We then performed meta-analyses with random-effects model. Results 80 case-control studies were included, of which 69 were graded as low or moderate quality. The majority of casecontrol studies were hospital-based and applied biomonitoring approaches to quantify metal levels after disease diagnosis. Studies on copper, iron, manganese and zinc were most prevalent. Meta-analyses showed no significant PD risk for these metals and heterogeneity among studies was substantial. Furthermore, 5 cohort studies were retained, but the population source, metal exposure and follow-up period were heterogeneous. Conclusion The level of evidence on metal exposure and PD risk is limited and no consensus can be drawn from the literature. Reverse causality cannot be ruled out by existing biomonitoring studies. Studies assessing metal levels before disease onset are needed to improve our understanding of the role of metals in the etiology of PD.
doi:10.1136/oem-2021-epi.260 fatcat:sg2u3ymwnree3g727di4i3l4ia