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A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice
[article]
2021
bioRxiv
pre-print
SARS-CoV-2 has infected almost 200 million humans and caused over 4 million deaths worldwide. Evaluating countermeasures and improving our understanding of COVID-19 pathophysiology require access to animal models that replicate the hallmarks of human disease. Mouse infection with SARS-CoV-2 is limited by poor affinity between the virus spike protein and its cellular receptor ACE2. We have developed by serial passages the MACo3 virus strain which efficiently replicates in the lungs of standard
doi:10.1101/2021.07.10.451880
fatcat:m23gyvf6bjf2tlavgkv6itqxma