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Demographic history and selection at HLA loci in Native Americans
The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history has shaped genetic variation at the strongly selected HLA loci. In order to disentangle the relative contributions of selection and demography process, we assembled a dataset with genome-wide microsatellites and HLA-A, -B, -C, and -DRB1 typing data for a setdoi:10.1371/journal.pone.0241282 pmid:33147239 fatcat:epnvckwvlbbcdnvrmlobnzufh4