Kinetic transition in model proteins with a denatured native spinodal

Jun Wang, Ke Fan, Wei Wang
2002 Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics  
The relaxation kinetics of three-dimensional lattice model proteins with Gō potential is studied. A kinetic transition from an exponential behavior to a nonexponential one with a denatured native spinodal is characterized. The transition temperatures T k , obtained from simulations and a semiquantitative estimation, are found to be the same. The change in free energy landscape during the transition is discussed microscopically by studying the detailed folding processes of various paths. The
more » ... ious paths. The connection of T k with the foldability is also studied by a Z-score-like quantity T f /T k .
doi:10.1103/physreve.65.041925 pmid:12005891 fatcat:7pchirn2yvcvjg22j3tbawbowa