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Applications of Mechanochemistry for the Synthesis of DNA on Ionic Liquid Supports
2021
Chemistry–Methods
The standard methodology for the synthesis of oligonucleotides is the solid-phase method. Here, we report the first case of mechanochemistry being directly applied to synthesising a dinucleotide on a soluble support. While mechanochemistry eliminates the need to solubilise a supported oligomer in the solution phase for phosphoramidite coupling, the support still confers the benefit of being able to purify the product by precipitation or by simple liquid-liquid extractions as needed.
doi:10.1002/cmtd.202100002
fatcat:yzzk4qhf2zbz3evpuxpqcycnjq