Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts

Levi P. Machado, Luciana R. Carvalho, Maria Cláudia M. Young, Elaine M. Cardoso-Lopes, Danilo C. Centeno, Leonardo Zambotti-Villela, Pio Colepicolo, Nair S. Yokoya
2015 Revista Brasileira de Farmacognosia  
Revista Brasileira de Farmacognosia 25 (2015) 657-662 w w w . s b f g n o s i a . o r g . b r / r e v i s t a Original Article a b s t r a c t Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a
more » ... med to carry out a quantitative and qualitative assessment of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400 g/ml. The chemical composition of the bioactive fraction was determined by gas chromatography-mass spectrometry (GC-MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them.
doi:10.1016/j.bjp.2015.09.003 fatcat:iwncrqkojrbu7by4s6g5rr2ena