"Apolipoprotein A-V Genetic Variants in Obese Children"

Guanghua Luo
2018 Interventions in Obesity & Diabetes  
Editorial Apolipoprotein A-V (APOA5) gene located on human 11q23 is an important determinant of plasma triglyceride levels [1] . Obese children with hyperinsulinemia had higher triglyceride (TG) level and lower APOA5 level than those without hyperinsulinemia and serum APOA5 was correlated negatively with TG level [2] . Single nucleotide polymorphisms (SNPs) of APOA5 were found to be significantly associated with plasma/serum TG levels in children [3] [4] [5] [6] [7] . SNP3 (ss3199915, now
more » ... into rs662799) of APOA5 gene was found to play an important role in the variation of serum TG levels. The serum TG levels of the subjects with C allele were significantly higher than those of the subjects with the T/T genotype. The TG levels of the subjects with the T/C and C/C genotype were 12.7% and 31.8% higher than those of the subjects with the T/T
doi:10.31031/iod.2018.01.000511 fatcat:odvrnzwvwvhmfor2xr5332lqla