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Suppression of polyclonal immunoglobulin production by M-proteins shows isotype specificity
Annals of Clinical and Laboratory Science
Monoclonal gammopathies are B cell neoplasms that are characterized by the presence of monoclonal immunoglobulins (M-proteins) in the serum. By an unknown mechanism, the normal polyclonal immunoglobulin levels are frequently reduced in sera of these patients. To assess the role of M-protein isotype in this effect, we used serum protein electrophoresis to quantitate monoclonal and polyclonal immunoglobulins in patients and we used serum immunofixation electrophoresis to determine their M-proteinpmid:11508831 fatcat:mtq3casajzht7p5n42x6gtvnri